37,701 research outputs found

    βCaMKII regulates bidirectional long-term plasticity in cerebellar Purkinje cells by a CaMKII/PP2B switch mechanism

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    This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise statedPeer reviewe

    The Phase Structure of the Weakly Coupled Lattice Schwinger Model

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    The weak coupling expansion is applied to the single flavour Schwinger model with Wilson fermions on a symmetric toroidal lattice of finite extent. We develop a new analytic method which permits the expression of the partition function as a product of pure gauge expectation values whose zeroes are the Lee-Yang zeroes of the model. Application of standard finite-size scaling techniques to these zeroes recovers previous numerical results for the small and moderate lattice sizes to which those studies were restricted. Our techniques, employable for arbitrarily large lattices, reveal the absence of accumulation of these zeroes on the real hopping parameter axis at constant weak gauge coupling. The consequence of this previously unobserved behaviour is the absence of a zero fermion mass phase transition in the Schwinger model with single flavour Wilson fermions at constant weak gauge coupling.Comment: 8 pages, 2 figures, insert to figure 2 include

    Experimental assessment and retrofit of full-scale models of existing RC frames

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    PSD tests on two full-scale models of existing non-seismic resisting RC frame structures are described. The testing program covered several aspects, namely assessment of seismic performance of existing frames without and with infill panels, retrofitting of the bare frame using Selective Retrofitting techniques, strengthening of the infill panels using shotcrete and retrofitting of the frame using K-bracing with shear-link dissipators. The main results from the tests are summarized and discussed and the conclusions are drawn. The tests on the bare frame have shown how vulnerable are existing structures constructed in the 60’s and the beneficial effects of infill panels were confirmed from the tests on the infilled frame. Important improvements, in terms of seismic performance, were achieved by the retrofitting of the frames. However, it was also confirmed that strengthening of the existing infill panels in poorly detailed frames may lead to dangerous ‘local’ failures, such as the shear out of the external columns
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